Spravato Ketamine Nasal Spray

Spravato Ketamine Nasal Spray


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You may benefit from adding SPRAVATO to your existing oral antidepressant if you’re an adult with major depressive disorder (MDD) who has had an inadequate response to two or more oral antidepressants, known as treatment-resistant depression (TRD).

What is Spravato?
SPRAVATO is the only FDA-approved nasal spray for TRD. SPRAVATO is an NMDA receptor antagonist that is believed to work differently by acting on a pathway in the brain that affects glutamate.

It is not known if SPRAVATO is safe and effective for use in preventing suicide or in reducing suicidal thoughts or actions. SPRAVATO is not for use in place of hospitalization if your healthcare provider determines that hospitalization is needed, even if improvement is experienced after the first dose of SPRAVATO.

Read more about it here: https://www.spravato.com/what-is-spravato#what-makes-spravato-different

How will I take SPRAVATO?

You will take SPRAVATO nasal spray yourself, under the supervision of a healthcare provider in a healthcare setting. Your healthcare provider will show you how to use the SPRAVATO nasal spray device.
Your healthcare provider will tell you how much SPRAVATO you will take and when you will take it.
Follow your SPRAVATO treatment schedule exactly as your healthcare provider tells you to.
During and after each use of the SPRAVATO nasal spray device, you will be checked by a healthcare provider who will decide when you are ready to leave the healthcare setting.
You will need to plan for a caregiver or family member to drive you home after taking SPRAVATO.
If you miss a SPRAVATO treatment, your healthcare provider may change your dose and treatment schedule.
Some people taking SPRAVATO get nausea and vomiting. You should not eat for at least 2 hours before taking SPRAVATO and not drink liquids at least 30 minutes before taking SPRAVATO®.
If you take a nasal corticosteroid or nasal decongestant medicine take these medicines at least 1 hour before taking SPRAVATO.
What should I avoid while taking SPRAVATO?

Do not drive, operate machinery, or do anything where you need to be completely alert after taking SPRAVATO®. Do not take part in these activities until the next day following a restful sleep. See “What is the most important information I should know about SPRAVATO?”

What are the possible side effects of SPRAVATO?

SPRAVATO may cause serious side effects including:

See “What is the most important information I should know about SPRAVATO?”
Increased blood pressure. SPRAVATO can cause a temporary increase in your blood pressure that may last for about 4 hours after taking a dose. Your healthcare provider will check your blood pressure before taking SPRAVATO and for at least 2 hours after you take SPRAVATO. Tell your healthcare provider right away if you get chest pain, shortness of breath, sudden severe headache, change in vision, or seizures after taking SPRAVATO.
Problems with thinking clearly. Tell your healthcare provider if you have problems thinking or remembering.
Bladder problems. Tell your healthcare provider if you develop trouble urinating, such as a frequent or urgent need to urinate, pain when urinating, or urinating frequently at night.
The most common side effects of SPRAVATO when used along with an antidepressant taken by mouth include:

feeling disconnected from yourself, your thoughts, feelings and things around you
feeling sleepy
spinning sensation
decreased feeling of sensitivity (numbness)
feeling anxious
lack of energy
increased blood pressure
feeling drunk
feeling very happy or excited